Here's some, from the top of my head.
There's more, but I'm forgetting them. Anyone else know?
- War Machine isn't featured in the comic, at all, which means you don't get the Iron Man/War Machine fight after Iron Man attacks Stingray.
- A lot of the villains from the comic were replaced by one's previously used in the show in season one. Blizzard and Blacklash don't appear in the book at all.
- The Ghost, the villain who sold the stolen technology to Justin Hammer in the cartoon doesn't appear in the book at all. In the book, another villain whose name escapes me sells the secrets to some of his villains.
- There's no nuclear explosion in the book.
- Iron Man fights Hawkeye in the cartoon and The Captain in the book.
- There's 'Hulkbuster' suit in the comic, simply a new red and gold armour, signaling the end of the red and blue/silver suit Iron Man was sporting at the time.
There's more, but I'm forgetting them. Anyone else know?