OsCorp being responsible for the radioactive spider is pretty much the standard origin story at this point.
I'm probably missing something, but it's funny how Spidey is wearing his traditional suit at the start of this short. Since this origin series (in which he'll most likely create his prototype suit) is told in flashback, I presume he'll be back in this getup by the end of the 6 animated shorts which I think are supposed to take place before the show starts. But then, he should be wearing the prototype again for at least the first few episodes of the show.
I'm probably missing something, but it's funny how Spidey is wearing his traditional suit at the start of this short. Since this origin series (in which he'll most likely create his prototype suit) is told in flashback, I presume he'll be back in this getup by the end of the 6 animated shorts which I think are supposed to take place before the show starts. But then, he should be wearing the prototype again for at least the first few episodes of the show.